body {
  font-family: "Segoe UI",Roboto,"Helvetica Neue",Arial,"Noto Sans",sans-serif,"Apple Color Emoji","Segoe UI Emoji","Segoe UI Symbol","Noto Color Emoji";
  
}

#logo {
  height: 50;
}

#icon {
  height: 30;
}

#logobig {
  height: 60;
}

#logobigger {
  height: 80;
}

#icon {
  height: 40;
}

p {
  margin-bottom: 0em;
}

input[disabled] {
  pointer-events: none;
  opacity: 40%;
}

.small {
  font-size: 0.8rem !important;
}

/* sweet modal */

.swal2-popup {
  font-size: 0.8rem !important;
  font-family: Georgia, serif;
}

.swal2-wide {
  width: 350px !important;
}


.wrapper_form {
  padding-left: 30px;
  display: grid;
  grid-template-columns: auto auto auto;
}



@media screen and (max-width: 1200px) {
  /* .cosita {
    display: flex;
    flex-wrap: wrap;
    background-color: green;
  } */

  .Nanowidth{
    margin-right: 2;
  }
}
@media (max-width:991px)
{
  .Nanowidth{
    width: 100%;
    padding-right: 0;
  }

}

@media (min-width:992px)
{
  
 .Nanotext {
   height: 190px;
 }
 .Nanoheight {
  height: 100%;
}

  .divHeight{
    height: 500px;
  }
  .Nanotext-en, .Nanotext-fr {
    height: 130px;
  }
  .Nanotext-es {
    height: 165px;
  }
  .Nanotext-it {
    height: 110px;
  }

  .ITStext-en {
    height: 145px;
  }
  .ITStext-es {
    height: 175px;
  }
  .ITStext-it{
    height: 125px;
  }
  .ITStext-fr{
    height: 150px;
  }
}

@media (min-width:1200px)
{
  .margen-es {
    margin-left: 20px;
  }
  
 .Nanotext-en {
   height: 125px;
 }
 .Nanotext-es {
   height: 130px;
 }
 .Nanotext-fr {
  height: 120px;
}

 .ITStext-es {
   height: 145px;
 }
 .ITStext-en {
  height: 140px;
}
.ITStext-fr{
  height: 135px;
}

 .divHeight{
  height: 450px;
}

}

.wrapper_form_one {
  padding-left: 30px;
  display: grid;
  grid-template-columns: auto;
}
/* 
.linkprotoPRED {
  color: black; /*#5b6868;*/
  font-weight: 700;
}
.linkprotoPRED:hover {
  color: #5b6868;;
  text-decoration: none;
  font-weight: 700; /*bold;*/
  filter: brightness(60%);
} */

/*------------------------------------------------------*/

/*------------------------Home design-------------------*/

/*------------------------------------------------------*/
ul#nav {
  list-style: none;
  margin: 0;
  padding: 0;
}
ul#nav li {
  float: left;
  width: 20%;
  text-align: center;
}
ul#nav li a {
  padding: 600px;
}
ul#nav li a:hover {
  color: #333;
}

.navbar-nav {
  padding-left: 20px;
}

.container-main-cover {
  padding: 0px 30px 0px 30px;
}

.container-main-cover_upper {
  padding: 5px 30px 0px 30px;
}

.container-main-cover_lefter {
  padding: 30px 0px 0px 15px;
}


.ProtoAPPdescriptiontext {
  text-align: center;
  vertical-align: middle;
  color: black;
  font-size: 18px;
}

.ProtoAPPdescriptiontext2 {
  text-align: center;
  vertical-align: middle;
  color: white;
  font-weight: 600;
}

.mid {
  z-index: 1;
  width: 450;
  position: absolute;
  margin-left: 30;
  margin-right: 35;
  margin-top: 145px;
  align-content: center;
}

.mid2 {
  z-index: 1;
  width: 450;
  position: absolute;
  margin-top: 145px;
  margin-left: 35;
  margin-right: 35;
  align-content: center;

}

.mid2 .column {
  width: 400px;
}
/*-------------------- BOXES ------------*/


/*--------------------Intento de hacer cosas genericas*/
.ProtoPREDmedbox {
  height: 195;
  width: 261;
  margin-top: 20px;
  margin-bottom: 20px;
  margin-right: 1px;
  margin-left: 1px;
}

.ProtoPREDbgimg_border_alone3 {
  width: 230;
  height: 160;
  float: left;
  margin: 20px 20px 20px 15px;
  border: 3px white solid;
  position: absolute;
  z-index: 1;
}

.ProtoPREDbgimg_border_alone_long {
  width: 359px;
  height: 170px;
  float: left;
  margin: 15px 20px 20px 20px;
  border: 3px white solid;
  position: absolute;
  z-index: 1;
}

.ProtoDescriptionGeneric {
  background-color: #d3c5bc;
  opacity: 0.8;
  height: 45;
  width: 200;
  margin-top: 95px;
  margin-left: 30px;
  z-index: 1;
  float: left;
  position: absolute;
  display: flex;
  justify-content: center;
  align-items: center;
}

.ProtoPREDlogoboxGeneric {
  background-repeat: no-repeat;
  background-position: center;
  background-color: white;
  height: 50;
  width: 200;
  margin-top: 30px;
  margin-left: 30px;
  float: right;
  position: absolute;
  z-index: 10;
}

.ProtoPREDlittleboxGeneric {
  height: 90;
}

.ProtoPREDbackgbox {
  background-size: 300px;
  opacity: 0.6;
  width: 310;
  height: 222;
  float: left;
  margin: 20px 20px 20px 20px;
}

.ProtoADMElogore {
  background-image: url("../../static/img/logos/ProtoADME.png");
  background-size: 160px;
}

.ProtoPHYSCHEMlogore {
  background-image: url("../../static/img/logos/ProtoPHYSCHEM.png");
  background-size: 160px;
}

.ProtoTOXlogore {
  background-image: url("../../static/img/logos/ProtoTOX.png");
  background-size: 160px;
}

.ProtoECOlogore {
  background-image: url("../../static/img/logos/ProtoECO.png");
  background-size: 160px;
}

.ProtoEDlogore {
  background-image: url("../../static/img/logos/ProtoED.png");
  background-size: 160px;
}

.ProtoPREDbckgboxGeneric {
  background-size: 275px;
  opacity: 0.6;
  width: 250;
  height: 160;
  float: left;
  margin-top: 20px;
}

.ProtoPREDbuttsGenerics {
  border: none;
  color: black;
  border-radius: 5px;
  margin-left: 0px;
  margin-right: 10px;
  margin-top: 3px;
  text-align: left;
  text-decoration: none;
  display: inline-block;
  font-size: 14px;
  width: 110px;
  padding: 1px 2px;
}

.ProtoPREDbutts_2Generics {
  border: none;
  color: black;
  border-radius: 5px;
  margin-left: 0px;
  margin-right: 10px;
  margin-top: 3px;
  text-align: center;
  text-decoration: none;
  display: inline-block;
  font-size: 14px;
  width: 80px;
  padding: 1px 2px;
}

.Prototext_description2 {
  text-align: justify;
  font-size: 20;
  margin-bottom: 50px;
  margin-top: 20px;
  margin-left: 20px;
}

.imagen{ 
  width: 400px;
  margin-left: 90px;
}

.textDescarga{
  font-size: large;
  font-weight: 1000;
}

/*--------------------------------------------------------------*/
.ProtoPREDbigbox {
  height: 200;
  width: 350;
  margin-top: 15px;
  margin-bottom: 30px;
  margin-left: 2px;
  margin-right: 2px;
}

.ProtoPREDbigbox2 {
  height: 200px;
  width: 400px;
  margin-bottom: 30px;
  margin-top: 15px;
  margin-left: 5px;
}
.ProtoPREDbigbox3 {
  height: 200px;
  width: 500px;
  margin-bottom: 30px;
  margin-top: 15px;
  margin-left: 5px;
}

.ProtoPREDlittlebox {
  height: 100;
}

.ProtoPREDbgimg_border_alone4 {
  width: 359px;
  height: 170px;
  float: left;
  margin: 15px 20px 20px 20px;
  border: 3px white solid;
  position: absolute;
  z-index: 1;
}

.ProtoPREDlogobox2 {
  background-repeat: no-repeat;
  background-position: center;
  background-color: white;
  height: 50;
  width: 450px;
  margin-top: 35px;
  margin-left: 30px;
  float: left;
  position: absolute;
  z-index: 10;
}


.ProtoPREDbgimg_border_alone2 {
  width: 310;
  height: 222;
  float: left;
  margin: 20px 20px 20px 20px;
  border: 3px white solid;
  position: absolute;
  z-index: 1;
}

.PROTOPREDsofter {
  background-color: #f8f8f8;
}

.ICHsofter {
  
  background-color: #fceffe;
}

.ICHsoft {
  background-color: #fad9ff;
  width: 400px;
}



.ICHdark {
  background-color: #e0c6e5;
}

.ICHdarkoutline {
  outline: 15px solid #e0c6e5;
}

.ICHdarker {
  color: #58167d;
}

.REACHsofter {
  background-color: #f3fbfd;
}

.REACHsoft {
  background-color: #e3f7fc;
  width: 400px;
}

.REACHdark {
  background-color: #d1e1e5;
}

.REACHdarkoutline {
  outline: 15px solid #d1e1e5;
}

.REACHdarker {
  color: #007caa;
}

.ADMEsofter {
  background-color: #fff7f3;
}

.ADMEsoft {
  background-color: #ffede1;
}

.ADMEdark {
  background-color: #d3c5bc;
}

.ADMEdarkoutline {
  outline: 15px solid #d3c5bc;
}

.ADMEdarker {
  color: #573f15;
}

.PHYSCHEMsofter {
  background-color: #fffef6;
}

.PHYSCHEMsoft {
  background-color: #fffde9;
}

.PHYSCHEMdark {
  background-color: #e8e6d6;
}

.PHYSCHEMdarkoutline {
  outline: 15px solid #e8e6d6;
}

.PHYSCHEMdarker {
  color: #738141;
}

.TOXsofter {
  background-color: #fff5f8;
}

.TOXsoft {
  background-color: #ffe6ee;
}

.TOXdark {
  background-color: #e2cfd6;
}

.TOXdarkoutline {
  outline: 15px solid #e2cfd6;
}

.TOXdarker {
  color: #a01127;
}

.ECOsofter {
  background-color: #f5faf9;
}

.ECOsoft {
  background-color: #e6f4f2;
}

.ECOdark {
  background-color: #d5e0de;
}

.ECOdarkoutline {
  outline: 15px solid #d5e0de;
}

.ECOdarker {
  color: #007464;
}


.NANOsofter {
  background-color: #ecf0ff;
}

.NANOsoft {
  background-color: #a2b4ff;
}

.NANOdark {
  background-color: #0f3f94;
}

.NANOdarkoutline {
  outline: 15px solid #0f3f94;
}

.NANOdarker {
  color: #0a2c67;
}


.GRAYdark {
  background-color: #686868;
}

/*-------------------- BOXES description ------------*/
.ProtoICHdescription {
  background-color: #e0c6e5;
  opacity: 0.8;
  height: 35;
  width: 337px;
  margin-top: 110px;
  margin-left: 30px;
  z-index: 1;
  float: left;
  position: absolute;
  display: flex;
  justify-content: center;
  align-items: center;

}

.ProtoREACHdescription {
  background-color: #d1e1e5;
  opacity: 0.8;
  height: 35;
  width: 337px;
  margin-top: 110px;
  margin-left: 30px;
  z-index: 1;
  float: left;
  position: absolute;
  display: flex;
  justify-content: center;
  align-items: center;

}

.ProtoADMEdescription {
  background-color: #d3c5bc;
  opacity: 0.8;
  height: 45;
  width: 215;
  margin-top: 95px;
  margin-left: 22px;
  z-index: 1;
  float: left;
  position: absolute;
  display: flex;
  justify-content: center;
  align-items: center;
}

.ProtoPHYSCHEMdescription {
  background-color: #e8e6d6;
  opacity: 0.8;
  height: 45;
  width: 215;
  margin-top: 95px;
  margin-left: 22px;
  z-index: 1;
  float: left;
  position: absolute;
  display: flex;
  justify-content: center;
  align-items: center;
}

.ProtoTOXdescription {
  background-color: #e2cfd6;
  opacity: 0.8;
  height: 45;
  width: 215;
  margin-top: 95px;
  margin-left: 22px;
  z-index: 1;
  float: left;
  position: absolute;
  display: flex;
  justify-content: center;
  align-items: center;
}

.ProtoECOdescription {
  background-color: #d5e0de;
  opacity: 0.8;
  height: 45;
  width: 215;
  margin-top: 95px;
  margin-left: 22px;
  z-index: 1;
  float: left;
  position: absolute;
  display: flex;
  justify-content: center;
  align-items: center;
  vertical-align: middle;

}

.ProtoEDdescription {
  background-color: #e2cfd6;
  opacity: 0.8;
  height: 45;
  width: 215;
  margin-top: 95px;
  margin-left: 22px;
  z-index: 1;
  float: left;
  position: absolute;
  display: flex;
  justify-content: center;
  align-items: center;
  vertical-align: middle;

}


/*-------------------- BOXES BACKGROUND ------------*/

.ProtoPREDbckgbox {
  background-size: 300px;
  opacity: 0.6;
  width: 310;
  height: 222;
  float: left;
  margin: 20px 20px 20px 20px;
}

.ProtoPREDbckgbox2 {
  background-size: 300px;
  opacity: 0.6;
  width: 460;
  height: 165;
  float: left;
  margin: 20px 20px 20px 15px;
}

.ProtoICHbckgimg {
  background-image: url("../../static/img/backgrounds/protoich-header_transparent.png");
  width: 348px;
}

.ProtoICHbckgimgtr {
  background-image: url("../../static/img/backgrounds/protoich-header_transparent.png");
}

.ProtoREACHbckgimg {
  background-image: url("../../static/img/backgrounds/protoreach-header_transparent.png");
  width: 348px;
}

.ProtoREACHbckgimgtr {
  background-image: url("../../static/img/backgrounds/protoreach-header_transparent.png");
}

.ProtoADMEbckgimg {
  background-image: url("../../static/img/backgrounds/protoadme-header_transparent.png");

}

.ProtoADMEbckgimgtr {
  background-image: url("../../static/img/backgrounds/protoadme-header_transparent.png");
}

.ProtoPHYSCHEMbckgimg {
  background-image: url("../../static/img/backgrounds/protophyschem-header_transparent.png");
}

.ProtoPHYSCHEMbckgimgtr {
  background-image: url("../../static/img/backgrounds/protophyschem-header_transparent.png");
}

.ProtoTOXbckgimg {
  background-image: url("../../static/img/backgrounds/prototox-header_transparent.png");
}

.ProtoTOXbckgimgtr {
  background-image: url("../../static/img/backgrounds/prototox-header_transparent.png");
}

.ProtoECObckgimg {
  background-image: url("../../static/img/backgrounds/protoeco-header_transparent.png");
}

.ProtoECObckgimgtr {
  background-image: url("../../static/img/backgrounds/protoeco-header_transparent.png");
}

.ProtoNANObckgimg {
  background-image: url("../../static/img/backgrounds/protonano-header_transparent.png");
  width: 355px;
}

.ProtoNANObckgimgtr {
  background-image: url("../../static/img/backgrounds/protonano-header_transparent.png");
}


/*-------------------- BOXES LOGO ------------*/

.ProtoPREDlogobox {
  background-repeat: no-repeat;
  background-position: center;
  background-color: white;
  height: 50;
  margin-top: 50px;
  margin-left: 30px;
  float: left;
  position: absolute;
  z-index: 10;
}

.ProtoICHlogo {
  background-image: url("../../static/img/logos/ProtoICH.png");
  background-size: 170px;
  width: 337px;
}

.ProtoREACHlogo {
  background-image: url("../../static/img/logos/ProtoREACH.png");
  background-size: 220px;
  width: 337px;
}

.ProtoADMElogo {
  background-image: url("../../static/img/logos/ProtoADME.png");
  background-size: 210px;
}

.ProtoPHYSCHEMlogo {
  background-image: url("../../static/img/logos/ProtoPHYSCHEM.png");
  background-size: 270px;
}

.ProtoTOXlogo {
  background-image: url("../../static/img/logos/ProtoTOX.png");
  background-size: 170px;
}

.ProtoECOlogo {
  background-image: url("../../static/img/logos/ProtoECO.png");
  background-size: 170px;
}

.ProtoNANOlogo {
  background-image: url("../../static/img/logos/ProtoNANO.png");
  background-size: 220px;
  width: 337px;
}



/*-------------------- BUTTONS ------------*/

.ProtoPREDbutts {
  border: none;
  color: black;
  border-radius: 5px;
  margin-left: 15px;
  margin-right: 15px;
  text-align: center;
  text-decoration: none;
  display: inline-block;
  font-size: 16px;
  width: 130px;
}

.ProtoPREDbutts_2 {
  border: none;
  color: black;
  border-radius: 5px;
  margin-left: 55px;
  margin-right: 15px;
  text-align: right;
  text-decoration: none;
  display: inline-block;
  font-size: 16px;
  width: 90px;
}

.ProtoPREDbutts_2_pequeño {
  border: none;
  color: black;
  border-radius: 5px;
  margin-right: 15px;
  margin-left: 150px;
  text-align: right;
  text-decoration: none;
  font-size: 16px;
  width: 90px;
}

.ProtoPREDbutts_2_big {
  border: none;
  color: black;
  border-radius: 5px;
  text-align: center;
  text-decoration: none;
  display: inline-block;
  font-size: 16px;
  width: 130px;
}

/*------------------------------------------------------*/

/*------------------------------------------------------*/

/*-------------------------Info pages-------------------*/

/*------------------------------------------------------*/

.f {
  position: absolute;
  width: 100%;
}

.wrapper {
  display: grid;
  grid-template-columns: auto auto auto auto;
}

.wrapper_two {
  display: grid;
  grid-template-columns: 50% 50%;
}

.wrapper_three {
  display: grid;
  grid-template-columns: 33% 33% 33%;
}

.wrapper_four {
  display: grid;
  grid-template-columns: 25% 25% 25% 25%;
}

.wrapper_five {
  display: grid;
  grid-template-columns: auto auto auto auto auto;
}

.ProtoAPPdescription-big {
  background-color: #686868;
  height: 100;
  margin-top: 50px;
  display: flex;
  justify-content: center;
  align-items: center;
  margin-left: 15;
}

.ProtoAPPdescriptiontext-big {
  text-align: center;
  vertical-align: middle;
  color: white;
  margin-left: 15;
  margin-right: 15;
}

.Prototext {
  /* text-align: justify; */
  vertical-align: middle;
  margin: 5px 5px 5px 5px;
}

.Prototext_description {
  text-align: center;
  vertical-align: middle;
  margin: 5px 5px 5px 5px;
}

.Prototext_description_reach_codes {
  text-align: center;
  vertical-align: middle;
  margin: 5px 5px 5px 5px;
  font-size: 1.2vw;
}

.GenoITStext {
  text-align: justify;
  vertical-align: middle;
  margin: 5px 5px 5px 5px;
  color: #ffffff
}

.GenoITStext_description {
  text-align: center;
  vertical-align: middle;
  margin: 5px 5px 5px 5px;
}

.GenoITStext_description_reach_codes {
  text-align: center;
  vertical-align: middle;
  margin: 5px 5px 5px 5px;
  font-size: 1.2vw;
}

.item_ProtoPRED_dark {
  margin: 10px 10px 10px 10px;
  background: #686868;
}

.ProtoPREDtext_grid_title_dark {
  text-align: center;
  vertical-align: middle;
  color: white;
  font-size: 1.3vw;
}

.containero_upper {
  height: 200;
  display: table;
  width: 100%;
  border: 3px white solid;
  position: relative;
}





.containero {
  display: table;
  width: 100%;
  border: 3px white solid;
  position: relative;
}

.item_ProtoPRED {
  margin: 10px 10px 10px 10px;
}

.padding_cb {
  padding-left: 30px;
}



.num1 {
  background-size: 300px;
  display: table-row;
}

.ProtoPREDlogoimg-big {
  background-size: 80%;
  background-repeat: no-repeat;
  background-position: center;
  background-color: white;
  height: 100;
  margin-top: 50px;
  margin-left: 20px;
}

.containero_text {
  display: table;
  width: 100%;
  border: 3px white solid;
  position: relative;
}

.ProtoPREDtext_grid_title {
  text-align: center;
  vertical-align: middle;
  font-size: 20px;
}

.ProtoPREDtext_grid_title_endpoints {
  text-align: center;
  vertical-align: middle;
  font-size: 1.3vw;
}

.ProtoPREDtext_grid_title_endpoints_little {
  text-align: center;
  vertical-align: middle;
  font-size: 1.2vw;
}

/*------------------------------------------------------*/


.buttondown {
  background-image: url("img/icons/ProtoPRED_download_icon.png");
  background-repeat: no-repeat;
  background-size: 100%;
  width: 20px;
  height: 20px;
  background-color: transparent;
  border: none;
  cursor: pointer;
  overflow: hidden;
  outline: none;
  padding-top: 15px;
  margin-left: 15px;
  opacity: 75%;
}

.alert {
  display: none;
  overflow: hidden;
}

.align-middle {
  padding-left: 5px;
}

.dropdown_menu {
  padding-left: 25px;
}

a:hover {
  color: black;
  text-decoration: none;
  font-weight: bold;
  filter: brightness(60%);
}

button:hover {
  color: black;
  text-decoration: none;
  font-weight: bold;
}

.wrap-login101 {
  width: 100%;
  height: 100%;
  background: #fff;
  border-radius: 10px;
  min-width: 1100px;
  padding: 10px 10px 10px 10px;
}

.div_justify {
  text-align: justify;
  text-justify: inter-word;
}

.wrap-loginhelp {
  border-width: 1px;
  padding: 10px 50px 10px 50px;
}

.wrap-login100 {
  border-radius: 10px;
  margin: 10px 0px 0px 0px;
}

.strech {
  border-radius: 10px;
  margin: auto;
  width: 70%;
}


.container-main {
  align-items: right;
  padding: 0px 0px 0px 30px;
  margin: 10px 0px 0px 0px;
}

.container-white_little_home {
  align-items: left;
  padding: 15px;
  border-radius: 10px;
}

.image_but_disabled {
  opacity: 0.1;
  pointer-events: none;
}

.label_alert_banner {
  font-size: 17px;
  margin-right: 5px;
}

/*---------------------------table----------------------*/

.table-bordered > tbody > tr > td,
.table-bordered > tbody > tr > th,
.table-bordered > tfoot > tr > td,
.table-bordered > tfoot > tr > th,
.table-bordered > thead > tr > td,
.table-bordered > thead > tr > th {
  border: 1px solid black;
  max-width: 200px;
  min-width: 50px;
  word-wrap: break-word;
  padding: 6px;
}


.table-bordered {
  display: block;
  max-height: 400px;
  overflow-y: auto;
  overflow-x: auto;
}

.about_text {
  border: none;
  color: black;
  text-align: left;
  text-decoration: none;
  display: block;
  font-size: 14px;
  padding: 5px 15px 10px 50px;
}

.about_title {
  border: none;
  color: black;
  text-align: left;
  text-decoration: bold;
  display: block;
  font-size: 16px;
  padding: 15px 15px 5px 10px;
}

/*-------------------------ProtoPRED--------------------*/

.containero_text_ProtoPRED {
  background-color: #bfc1c1;
  display: table;
  width: 100%;
  border: 3px white solid;
  outline: 15px solid #bfc1c1;
  position: relative;
}

.containero_text_ProtoPRED2 {
  background-color: white;
  display: table;
  width: 100%;
  border: 3px white solid;
  position: relative;
}

.centered_div {
  display: flex;
  justify-content: center;
}

.grey_text {
  color: grey;
}

.containero_text_ProtoPRED3 {
  background-color: #f8f8f8;
  display: table;
  width: 100%;
  border: 3px white solid;
  outline: 15px solid white;
  position: relative;
}

.container-ProtoPRED_soft {
  align-items: left;
  padding: 15px;
  border-radius: 10px;
  background: #eff1f1;
}

.container-ProtoPRED_white {
  align-items: left;
  padding: 15px;
  border-radius: 10px;
}

.container-ProtoPRED_dark {
  background-color: #5b6868;
  border-radius: 10px;
  overflow: hidden;
  padding: 10px 10px 10px 10px;
  display: -webkit-box;
  display: -webkit-flex;
  display: -moz-box;
  display: -ms-flexbox;
  display: flex;
  flex-wrap: wrap;
  justify-content: center;
  align-items: center;
}

.row-ProtoPRED_soft {
  background-color: #eff1f1;
  border-radius: 10px;
  overflow: hidden;
  width: 98%;
  float: left;
  margin: 10px;
  display: block;
  text-align: left;
  padding: 10px;
}

.row-ProtoPRED_soft_marg {
  background-color: #eff1f1;
  border-radius: 10px;
  width: 98%;
  margin: 15px;
  display: block;
  text-align: center;
  padding: 10px;
}

.button-ProtoPRED_HELP_LINKS {
  border: none;
  color: black;
  border-radius: 8px;
  text-align: center;
  text-decoration: none;
  display: inline-block;
  font-size: 16px;
  padding: 10px 10px 10px 10px;
}

.button-ProtoPRED_dark_pair {
  background-color: #8c9595;
  border: none;
  color: black;
  border-radius: 8px;
  padding: 5px 10px;
  margin-top: 15px;
  text-align: center;
  text-decoration: none;
  display: inline-block;
  font-size: 16px;
}

.button-ProtoPRED_dark_alone {
  background-color: #8c9595;
  border: none;
  color: black;
  border-radius: 8px;
  padding: 5px 10px;
  text-align: center;
  text-decoration: none;
  display: inline-block;
  font-size: 16px;
}
.button-ProtoPRED_dark_alone_marge {
  background-color: #8c9595;
  border: none;
  color: black;
  border-radius: 8px;
  padding: 3px 10px;
  text-align: center;
  text-decoration: none;
  display: inline-block;
  font-size: 16px;
  margin-right: 20px;
}

input[type="image"]:hover {
  filter: brightness(50%);
}

/*-------------------------ProtoREACH--------------------*/

.container-ProtoREACH_soft {
  align-items: left;
  padding: 15px;
  border-radius: 10px;
  background: #eff6f9;
}

.container-ProtoREACH_dark {
  background-color: #afd4e4;
  border-radius: 10px;
  overflow: hidden;
  padding: 10px 10px 10px 10px;
  margin-bottom: 10px;
  display: -webkit-box;
  display: -webkit-flex;
  display: -moz-box;
  display: -ms-flexbox;
  display: flex;
  flex-wrap: wrap;
  justify-content: center;
  align-items: center;
}

.row-ProtoREACH_soft {
  background-color: #eff6f9;
  border-radius: 10px;
  overflow: hidden;
  width: 98%;
  float: left;
  margin: 10px;
  display: block;
  text-align: left;
  padding-left: 10px;
  padding-top: 10px;
}

input.button-QMRF_ProtoREACH {
  outline: none !important;
  border: none;
  background: transparent;
  background-color: #afd4e4;
  border-radius: 8px;
  padding: 3px 5px;
  width: 70px;
  text-align: center;
  cursor: pointer;
}

input.button-QMRF_ProtoREACH:hover {
  color: black;
  text-decoration: none;
  font-weight: bold;
}

.button-ProtoREACH_dark_alone {
  background-color: #afd4e4;
  border: none;
  color: black;
  border-radius: 8px;
  padding: 5px 10px;
  text-align: center;
  text-decoration: none;
  display: inline-block;
  font-size: 16px;
}

.button-ProtoREACH_dark_pair {
  background-color: #afd4e4;
  border: none;
  color: black;
  border-radius: 8px;
  padding: 5px 10px;
  margin-top: 15px;
  text-align: center;
  text-decoration: none;
  display: inline-block;
  font-size: 16px;
}

.button-ProtoREACH_soft_pair {
  background-color: #eff6f9;
  border: none;
  color: black;
  border-radius: 8px;
  padding: 5px 10px;
  margin-left: 20px;
  text-align: center;
  text-decoration: none;
  display: inline-block;
  font-size: 16px;
}

.button-ProtoREACH_dark_alone[disabled] {
  background-color: #afd4e4;
  border: none;
  opacity: 0.5;
  color: #000000;
  border-radius: 8px;
  padding: 5px 10px;
  text-align: center;
  text-decoration: none;
  display: inline-block;
  font-size: 16px;
}

.button-ProtoREACH_dark_pair[disabled] {
  background-color: #afd4e4;
  border: none;
  opacity: 0.5;
  color: #000000;
  border-radius: 8px;
  padding: 5px 10px;
  margin-top: 15px;
  text-align: center;
  text-decoration: none;
  display: inline-block;
  font-size: 16px;
}

/*-------------------------ProtoPHYSCHEM--------------------*/

.container-ProtoPHYSCHEM_soft {
  align-items: left;
  padding: 15px;
  border-radius: 10px;
  background: #f3f3ed;
}

.container-ProtoPHYSCHEM_dark {
  background-color: #c4c4a5;
  border-radius: 10px;
  overflow: hidden;
  padding: 10px 10px 10px 10px;
  margin-bottom: 10px;
  display: -webkit-box;
  display: -webkit-flex;
  display: -moz-box;
  display: -ms-flexbox;
  display: flex;
  flex-wrap: wrap;
  justify-content: center;
  align-items: center;
}

.row-ProtoPHYSCHEM_soft {
  background-color: #f3f3ed;
  border-radius: 10px;
  overflow: hidden;
  width: 98%;
  float: left;
  margin: 10px;
  display: block;
  text-align: left;
  padding-left: 10px;
  padding-top: 10px;
}

input.button-QMRF_ProtoPHYSCHEM {
  outline: none !important;
  border: none;
  background: transparent;
  background-color: #c4c4a5;
  border-radius: 8px;
  padding: 3px 5px;
  width: 70px;
  text-align: center;
  cursor: pointer;
}

input.button-QMRF_ProtoPHYSCHEM:hover {
  color: black;
  text-decoration: none;
  font-weight: bold;
}

.button-ProtoPHYSCHEM_dark_alone {
  background-color: #c4c4a5;
  border: none;
  color: black;
  border-radius: 8px;
  padding: 5px 10px;
  text-align: center;
  text-decoration: none;
  display: inline-block;
  font-size: 16px;
}

.button-ProtoPHYSCHEM_dark_pair {
  background-color: #c4c4a5;
  border: none;
  color: black;
  border-radius: 8px;
  padding: 5px 10px;
  margin-top: 15px;
  text-align: center;
  text-decoration: none;
  display: inline-block;
  font-size: 16px;
}

.button-ProtoPHYSCHEM_soft_pair {
  background-color: #f3f3ed;
  border: none;
  color: black;
  border-radius: 8px;
  padding: 5px 10px;
  margin-left: 20px;
  text-align: center;
  text-decoration: none;
  display: inline-block;
  font-size: 16px;
}

.button-ProtoPHYSCHEM_dark_alone[disabled] {
  background-color: #c4c4a5;
  border: none;
  opacity: 0.5;
  color: #000000;
  border-radius: 8px;
  padding: 5px 10px;
  text-align: center;
  text-decoration: none;
  display: inline-block;
  font-size: 16px;
}

.button-ProtoPHYSCHEM_dark_pair[disabled] {
  background-color: #c4c4a5;
  border: none;
  opacity: 0.5;
  color: #000000;
  border-radius: 8px;
  padding: 5px 10px;
  margin-top: 15px;
  text-align: center;
  text-decoration: none;
  display: inline-block;
  font-size: 16px;
}

/*-------------------------ProtoTOX--------------------*/

.container-ProtoTOX_soft {
  align-items: left;
  padding: 15px;
  border-radius: 10px;
  background: #f7e6e9;
}

.container-ProtoTOX_dark {
  background-color: #d88492;
  border-radius: 10px;
  overflow: hidden;
  padding: 10px 10px 10px 10px;
  margin-bottom: 10px;
  display: -webkit-box;
  display: -webkit-flex;
  display: -moz-box;
  display: -ms-flexbox;
  display: flex;
  flex-wrap: wrap;
  justify-content: center;
  align-items: center;
}

.row-ProtoTOX_soft {
  background-color: #f7e6e9;
  border-radius: 10px;
  overflow: hidden;
  width: 98%;
  float: left;
  margin: 10px;
  display: block;
  text-align: left;
  padding-left: 10px;
  padding-top: 10px;
}

input.button-QMRF_ProtoTOX {
  outline: none !important;
  border: none;
  background: transparent;
  background-color: #d88492;
  border-radius: 8px;
  padding: 3px 5px;
  width: 70px;
  text-align: center;
  cursor: pointer;
}

input.button-QMRF_ProtoTOX:hover {
  color: black;
  text-decoration: none;
  font-weight: bold;
}

.button-ProtoTOX_dark_alone {
  background-color: #d88492;
  border: none;
  color: black;
  border-radius: 8px;
  padding: 5px 10px;
  text-align: center;
  text-decoration: none;
  display: inline-block;
  font-size: 16px;
}

.button-ProtoTOX_dark_pair {
  background-color: #d88492;
  border: none;
  color: black;
  border-radius: 8px;
  padding: 5px 10px;
  margin-top: 15px;
  text-align: center;
  text-decoration: none;
  display: inline-block;
  font-size: 16px;
}

.button-ProtoTOX_soft_pair {
  background-color: #f7e6e9;
  border: none;
  color: black;
  border-radius: 8px;
  padding: 5px 10px;
  margin-left: 20px;
  text-align: center;
  text-decoration: none;
  display: inline-block;
  font-size: 16px;
}

.button-ProtoTOX_dark_alone[disabled] {
  background-color: #d88492;
  border: none;
  opacity: 0.5;
  color: #000000;
  border-radius: 8px;
  padding: 5px 10px;
  text-align: center;
  text-decoration: none;
  display: inline-block;
  font-size: 16px;
}

.button-ProtoTOX_dark_pair[disabled] {
  background-color: #d88492;
  border: none;
  opacity: 0.5;
  color: #000000;
  border-radius: 8px;
  padding: 5px 10px;
  margin-top: 15px;
  text-align: center;
  text-decoration: none;
  display: inline-block;
  font-size: 16px;
}

/*-------------------------ProtoECO--------------------*/

.container-ProtoECO_soft {
  align-items: left;
  padding: 15px;
  border-radius: 10px;
  background: #eff5f4;
}

.container-ProtoECO_dark {
  background-color: #afd0cc;
  border-radius: 10px;
  overflow: hidden;
  padding: 10px 10px 10px 10px;
  margin-bottom: 10px;
  display: -webkit-box;
  display: -webkit-flex;
  display: -moz-box;
  display: -ms-flexbox;
  display: flex;
  flex-wrap: wrap;
  justify-content: center;
  align-items: center;
}

.row-ProtoECO_soft {
  background-color: #eff5f4;
  border-radius: 10px;
  overflow: hidden;
  width: 98%;
  float: left;
  margin: 10px;
  display: block;
  text-align: left;
  padding-left: 10px;
  padding-top: 10px;
}

input.button-QMRF_ProtoECO {
  outline: none !important;
  border: none;
  background: transparent;
  background-color: #afd0cc;
  border-radius: 8px;
  padding: 3px 5px;
  width: 70px;
  text-align: center;
  cursor: pointer;
}

input.button-QMRF_ProtoECO:hover {
  color: black;
  text-decoration: none;
  font-weight: bold;
}

.button-ProtoECO_dark_alone {
  background-color: #afd0cc;
  border: none;
  color: black;
  border-radius: 8px;
  padding: 5px 10px;
  text-align: center;
  text-decoration: none;
  display: inline-block;
  font-size: 16px;
}

.button-ProtoECO_dark_pair {
  background-color: #afd0cc;
  border: none;
  color: black;
  border-radius: 8px;
  padding: 5px 10px;
  margin-top: 15px;
  text-align: center;
  text-decoration: none;
  display: inline-block;
  font-size: 16px;
}

.button-ProtoECO_soft_pair {
  background-color: #eff5f4;
  border: none;
  color: black;
  border-radius: 8px;
  padding: 5px 10px;
  margin-left: 20px;
  text-align: center;
  text-decoration: none;
  display: inline-block;
  font-size: 16px;
}

.button-ProtoECO_dark_alone[disabled] {
  background-color: #afd0cc;
  border: none;
  opacity: 0.5;
  color: #000000;
  border-radius: 8px;
  padding: 5px 10px;
  text-align: center;
  text-decoration: none;
  display: inline-block;
  font-size: 16px;
}

.button-ProtoECO_dark_pair[disabled] {
  background-color: #afd0cc;
  border: none;
  opacity: 0.5;
  color: #000000;
  border-radius: 8px;
  padding: 5px 10px;
  margin-top: 15px;
  text-align: center;
  text-decoration: none;
  display: inline-block;
  font-size: 16px;
}

/*-------------------------ProtoICH--------------------*/

.container-ProtoICH_soft {
  align-items: left;
  padding: 15px;
  border-radius: 10px;
  background: #f1e6f2;
}

.container-ProtoICH_dark {
  background-color: #bd84bf;
  border-radius: 10px;
  overflow: hidden;
  padding: 10px 10px 10px 10px;
  margin-bottom: 10px;
  display: -webkit-box;
  display: -webkit-flex;
  display: -moz-box;
  display: -ms-flexbox;
  display: flex;
  flex-wrap: wrap;
  justify-content: center;
  align-items: center;
}

.row-ProtoICH_soft {
  background-color: #f1e6f2;
  border-radius: 10px;
  overflow: hidden;
  width: 98%;
  float: left;
  margin: 10px;
  display: block;
  text-align: left;
  padding-left: 10px;
  padding-top: 10px;
}

input.button-QMRF_ProtoICH {
  outline: none !important;
  border: none;
  background: transparent;
  background-color: #bd84bf;
  border-radius: 8px;
  padding: 3px 5px;
  width: 70px;
  text-align: center;
  cursor: pointer;
}

input.button-QMRF_ProtoICH:hover {
  color: black;
  text-decoration: none;
  font-weight: bold;
}

.button-ProtoICH_dark_alone {
  background-color: #bd84bf;
  border: none;
  color: black;
  border-radius: 8px;
  padding: 5px 10px;
  text-align: center;
  text-decoration: none;
  display: inline-block;
  font-size: 16px;
}

.button-ProtoICH_dark_pair {
  background-color: #bd84bf;
  border: none;
  color: black;
  border-radius: 8px;
  padding: 5px 10px;
  margin-top: 15px;
  text-align: center;
  text-decoration: none;
  display: inline-block;
  font-size: 16px;
}

.button-ProtoICH_soft_pair {
  background-color: #f1e6f2;
  border: none;
  color: black;
  border-radius: 8px;
  padding: 5px 10px;
  margin-left: 20px;
  text-align: center;
  text-decoration: none;
  display: inline-block;
  font-size: 16px;
}

.button-ProtoICH_dark_alone[disabled] {
  background-color: #bd84bf;
  border: none;
  opacity: 0.5;
  color: #000000;
  border-radius: 8px;
  padding: 5px 10px;
  text-align: center;
  text-decoration: none;
  display: inline-block;
  font-size: 16px;
}

.button-ProtoICH_dark_pair[disabled] {
  background-color: #bd84bf;
  border: none;
  opacity: 0.5;
  color: #000000;
  border-radius: 8px;
  padding: 5px 10px;
  margin-top: 15px;
  text-align: center;
  text-decoration: none;
  display: inline-block;
  font-size: 16px;
}

/*-------------------------ProtoADME--------------------*/

.container-ProtoADME_soft {
  align-items: left;
  padding: 15px;
  border-radius: 10px;
  background: #ffe6d5;
}

.container-ProtoADME_dark {
  background-color: #a8631e;
  border-radius: 10px;
  overflow: hidden;
  padding: 10px 10px 10px 10px;
  margin-bottom: 10px;
  display: -webkit-box;
  display: -webkit-flex;
  display: -moz-box;
  display: -ms-flexbox;
  display: flex;
  flex-wrap: wrap;
  justify-content: center;
  align-items: center;
}

.row-ProtoADME_soft {
  background-color: #ffe6d5;
  border-radius: 10px;
  overflow: hidden;
  width: 98%;
  float: left;
  margin: 10px;
  display: block;
  text-align: left;
  padding-left: 10px;
  padding-top: 10px;
  padding-right: 10px;
}

input.button-QMRF_ProtoADME {
  outline: none !important;
  border: none;
  background: transparent;
  background-color: #a8631e;
  border-radius: 8px;
  padding: 3px 5px;
  width: 70px;
  text-align: center;
  cursor: pointer;
}

.button-ProtoADME_dark_alone {
  background-color: #a8631e;
  border: none;
  color: black;
  border-radius: 8px;
  padding: 5px 10px;
  text-align: center;
  text-decoration: none;
  display: inline-block;
  font-size: 16px;
}

.button-ProtoADME_dark_pair {
  background-color: #a8631e;
  border: none;
  color: black;
  border-radius: 8px;
  padding: 5px 10px;
  margin-top: 15px;
  text-align: center;
  text-decoration: none;
  display: inline-block;
  font-size: 16px;
}

.button-ProtoADME_soft_pair {
  background-color: #ffe6d5;
  border: none;
  color: black;
  border-radius: 8px;
  padding: 5px 10px;
  margin-left: 20px;
  text-align: center;
  text-decoration: none;
  display: inline-block;
  font-size: 16px;
}

.button-ProtoADME_dark_alone[disabled] {
  background-color: #a8631e;
  border: none;
  opacity: 0.5;
  color: #000000;
  border-radius: 8px;
  padding: 5px 10px;
  text-align: center;
  text-decoration: none;
  display: inline-block;
  font-size: 16px;
}

.button-ProtoADME_dark_pair[disabled] {
  background-color: #a8631e;
  border: none;
  opacity: 0.5;
  color: #000000;
  border-radius: 8px;
  padding: 5px 10px;
  margin-top: 15px;
  text-align: center;
  text-decoration: none;
  display: inline-block;
  font-size: 16px;
}

/*---------------------------------------------*/

.flags {
  column-count: 4;
  grid-template-rows: 4;
  column-gap: 12px;
  padding-left: 10px;
  padding-top: 10px;
  border-left: 1px solid black;
}

.for_icons {
  column-count: 2;
  grid-template-rows: 2;
  padding-top: 10px;
}

.right2 {
  margin-left: 200px;
}

.left3 {
  width: 50%;
  padding-left: 10px;
}

.right3 {
  width: 40%;
}

.left4 {
  width: 45%;
  padding-left: 10px;
  margin-left: 10px;
}

.right4 {
  width: 45%;
  padding-left: 10px;
  margin-left: 10px;
}

.left47_5 {
  width: 47.5%;
  padding-left: 10px;
  margin-left: 10px;
}

.right47_5 {
  width: 47.5%;
  padding-left: 10px;
  margin-left: 10px;
}

.left60_35 {
  width: 60%;
  padding-left: 10px;
  margin-left: 10px;
}

.right60_35 {
  width: 35%;
  padding-left: 10px;
  margin-left: 10px;
}

.left55_40 {
  width: 57%;
  padding-left: 10px;
  margin-left: 10px;
}

.right55_40 {
  width: 38%;
  padding-left: 10px;
  margin-left: 10px;
}

.left5 {
  width: 89%;
  padding-left: 10px;
  margin-left: 10px;
}
.endpoint_input {
  width:100%;
  display: flex;
}

.label_endpoint {
  width: 440px;
  display: inline-block;
}

.label_endpoint_little {
  vertical-align: text-top;
}

.label_endpoint_qmrf {
  width: 20px;
  font-style: italic;
  font-size: 14px;
  vertical-align: text-top;
  display: inline-block;
  
}
.label_endpoint_ADME {
  width: 320px;
  display: inline-block;
}

.qmrf_block {
  width: 60px; 
  flex:none;
  float: right;
  margin-right: 10px;
  vertical-align: text-top;
}
.endpoint_label_block {
  width:100%;
}

.endpoint_cb_block {
  margin-right:5px;
}

.endpoint_checkbox {
  vertical-align: text-top;
  margin-top:6px;
}




/*---------------------------------------------*/

.additional_info_title {
  margin-left: 30px;
}

.additional_info {
  margin-left: 50px;
}

.little {
  font-size: 13px;
  margin-left: 30px;
}

.little2 {
  font-size: 13px;
  margin-left: 30px;
  margin-top: 15px;
}

/*---------------------------------------------*/

label.white {
  font-weight: bold;
  margin: 5px 0;
  color: white;
  display: inline-block;
  text-align: left;
  width: 95%;
}

label.grey {
  margin: 5px 0;
  color: grey;
  display: inline-block;
  text-align: left;
  width: 95%;
}

label.version {
  font-weight: bold;
  background-color: red;
  border-radius: 8px;
  color: white;
  display: inline-block;
  text-align: center;
  padding: 5px 5px 5px 5px;
  width: 10%;
}

label.comments {
  margin: 5px 0;
  color: white;
  display: inline-block;
  text-align: left;
  width: 95%;
}

label.indented {
  padding: 15px 0px 0px 15px;
}

/*---------------------------------------------*/

input[type="text0"] {
  width: 90%;
  padding-left: 10px;
  border-radius: 8px;
  margin-left: 20px;
  margin-bottom: 10px;
  border: #999999 1px solid;
  background-color: white;
}

input[type="email"] {
  width: 90%;
  padding-left: 10px;
  border-radius: 8px;
  margin-left: 20px;
  margin-bottom: 10px;
  border: #999999 1px solid;
  background-color: white;
}

input[type="text2_1"] {
  padding-left: 10px;
  margin-left: 20px;
  margin-bottom: 20px;
  width: 60%;
  border-radius: 8px;
  border: #999999 1px solid;
  background-color: white;
}

input[type="text2"] {
  padding-left: 10px;
  margin-left: 20px;
  margin-bottom: 20px;
  width: 90%;
  border-radius: 8px;
  border: #999999 1px solid;
  background-color: white;
}

input[type="text3"] {
  width: 60%;
  padding-left: 10px;
  margin-left: 60px;
}

input[type="text"]:disabled {
  background-color: #e6e6e6;
}

input[type="text2"]:disabled {
  background-color: #e6e6e6;
}

input[type="text3"]:disabled {
  background-color: #e6e6e6;
}


/*---------------------------------------------*/

textarea {
  outline: none;
  border: none;
  /* border: 1px solid #c80000; */
}

textarea.multiline {
  white-space: normal;
  height: calc(5 * 28px);
  border-radius: 8px;
  width: 95%;
  margin: 5px 5px 5px 5px;
  border: #999999 1px solid;
}


textarea.multiline2 {
  padding-left: 10px;
  white-space: normal;
  width: 90%;
  height: calc(2 * 28px);
  border-radius: 8px;
  margin: 5px 5px 5px 20px;
  border: #999999 1px solid;
}

textarea.multiline_flex {
  padding-left: 10px;
  white-space: normal;
  width: 90%;
  height: calc(1 * 28px);
  border-radius: 8px;
  margin: 5px 5px 5px 20px;
  border: #999999 1px solid;
}

textarea.multiline_flex:focus {
  height: calc(5 * 28px);
  
}

textarea:focus,
input:focus {
  border-color: transparent !important;
}


.multilinebig {
  white-space: normal;
  width: 92%;
  border-radius: 8px;
  margin: 5px 5px 5px 5px;
  border: #999999 1px solid;
}

textarea.multiline:disabled {
  background-color: #e6e6e6;
}

textarea:focus,
input:focus {
  border-color: transparent !important;
}

:focus {
  outline: none !important;
}


/*---------------------------------------------*/

input.button-QMRF {
  outline: none !important;
  border: none;
  background-color: #292f2f;
  border-radius: 8px;
  width: 50px;
  text-align: center;
  cursor: pointer;
}

.button-Annex {
  border: none;
  color: black;
  border-radius: 8px;
  padding: 5px 10px;
  text-align: center;
  text-decoration: none;
  display: inline-block;
  font-size: 16px;
}

.button-Group {
  border: none;
  color: black;
  border-radius: 8px;
  padding: 5px 10px;
  margin-left: 20px;
  text-align: center;
  text-decoration: none;
  display: inline-block;
  font-size: 16px;
}

#WindowLoad {
  position: fixed;
  top: 0px;
  left: 0px;
  z-index: 3200;
  filter: alpha(opacity=65);
  -moz-opacity: 65;
  opacity: 0.65;
  background: #999;
}

/* Tooltip container */
.tooltip {
  position: relative;
  display: inline-block;
  border-bottom: 1px dotted black; /* If you want dots under the hoverable text */
}

/* Tooltip text */
.tooltip .tooltiptext {
  visibility: hidden;
  width: 120px;
  background-color: black;
  color: #fff;
  text-align: center;
  padding: 5px 0;
  border-radius: 6px;

  /* Position the tooltip text - see examples below! */
  position: absolute;
  z-index: 1;
}

/* Show the tooltip text when you mouse over the tooltip container */
.tooltip:hover .tooltiptext {
  visibility: visible;
}


.SMILES_list {
  width: 90%;
}


#icon_question {
  width: 18px;
  height: 18px;
  margin-bottom: 0.5rem
}

.GenoITSsofter {
  background-color: #f5faf9;
}

.GenoITSsoft {
  background-color: #9DBBA2;
}

.GenoITSdark {
  background-color: #3A7644;
}

.ProtoNANOdark {
  background-color: #0f3f94;
}

.ProtoNANOsoft{
  background-color: #7E9EFF;
}

.GenoITSdarkoutline {
  outline: 15px solid #d5e0de;
}

.GenoITSdarker {
  color: #007464;
}

.ProtoNANOdescription {
  background-color: #d5e0de;
  opacity: 0.8;
  height: 35;
  width: 337px;
  margin-top: 110px;
  margin-left: 30px;
  z-index: 1;
  float: left;
  position: absolute;
  display: flex;
  justify-content: center;
  align-items: center;

}


.GenoITSdescription {
  background-color: #d5e0de;
  opacity: 0.8;
  height: 35;
  width: 450px;
  margin-top: 115px;
  margin-left: 30px;
  z-index: 1;
  float: left;
  position: absolute;
  display: flex;
  justify-content: center;
  align-items: center;

}

.GenoITSbckgimg {
  background-image: url("../../static/img/backgrounds/protoich-header_transparent.png");
  width: 348px;
}

.GenoITSbckgimgtr {
  background-image: url("../../static/img/backgrounds/protoich-header_transparent.png");
}

.GenoITSlogo {
  background-image: url("../../static/img/logos/GenoITS.png");
  background-size: 170px;
  width: 337px;
}

/*-------------------------GenoITS--------------------*/

.container-GenoITS_soft {
  align-items: left;
  padding: 15px;
  border-radius: 10px;
  background: #eff5f4;
}

.container-GenoITS_dark {
  background-color: #47d45f;
  border-radius: 10px;
  overflow: hidden;
  padding: 10px 10px 10px 10px;
  margin-bottom: 10px;
  display: -webkit-box;
  display: -webkit-flex;
  display: -moz-box;
  display: -ms-flexbox;
  display: flex;
  flex-wrap: wrap;
  justify-content: center;
  align-items: center;
}

.row-GenoITS_soft {
  background-color: #C8D7C8;
  border-radius: 10px;
  overflow: hidden;
  width: 98%;
  float: left;
  margin: 10px;
  display: block;
  text-align: left;
  padding-left: 10px;
  padding-top: 10px;
  padding-right: 10px;
}

.button-GenoITS_soft_pair {
  background-color: #C8D7C8;
  border: none;
  color: black;
  border-radius: 8px;
  padding: 5px 10px;
  margin-left: 20px;
  text-align: center;
  text-decoration: none;
  display: inline-block;
  font-size: 16px;
}

input.button-QMRF_GenoITS {
  outline: none !important;
  border: none;
  background: transparent;
  background-color: #afd0cc;
  border-radius: 8px;
  padding: 3px 5px;
  width: 70px;
  text-align: center;
  cursor: pointer;
}

input.button-QMRF_GenoITS:hover {
  color: black;
  text-decoration: none;
  font-weight: bold;
}

.button-GenoITS_dark_alone {
  background-color: #afd0cc;
  border: none;
  color: black;
  border-radius: 8px;
  padding: 5px 10px;
  text-align: center;
  text-decoration: none;
  display: inline-block;
  font-size: 16px;
}

.button-GenoITS_dark_pair {
  background-color: #afd0cc;
  border: none;
  color: black;
  border-radius: 8px;
  padding: 5px 10px;
  margin-top: 15px;
  text-align: center;
  text-decoration: none;
  display: inline-block;
  font-size: 16px;
}

.button-GenoITS_soft_pair {
  background-color: #eff5f4;
  border: none;
  color: black;
  border-radius: 8px;
  padding: 5px 10px;
  margin-left: 20px;
  text-align: center;
  text-decoration: none;
  display: inline-block;
  font-size: 16px;
}

.button-GenoITS_dark_alone[disabled] {
  background-color: #afd0cc;
  border: none;
  opacity: 0.5;
  color: #000000;
  border-radius: 8px;
  padding: 5px 10px;
  text-align: center;
  text-decoration: none;
  display: inline-block;
  font-size: 16px;
}

.button-GenoITS_dark_pair[disabled] {
  background-color: #afd0cc;
  border: none;
  opacity: 0.5;
  color: #000000;
  border-radius: 8px;
  padding: 5px 10px;
  margin-top: 15px;
  text-align: center;
  text-decoration: none;
  display: inline-block;
  font-size: 16px;
}



@media (max-width:1300px)
{
  .ProtoPREDbigbox.Vacio {
    margin-top: 15px;
    width: 0;
    max-width: 80vw;
    height: 0;
  }

}




button-ProtoNANO_dark_pair/*-------------------------ProtoREACH--------------------*/

.container-ProtoNANO_soft {
  align-items: left;
  padding: 15px;
  border-radius: 10px;
  background: #eff6f9;
}

.container-ProtoNANO_dark {
  background-color: #0d7cab;
  border-radius: 10px;
  overflow: hidden;
  padding: 10px 10px 10px 10px;
  margin-bottom: 10px;
  display: -webkit-box;
  display: -webkit-flex;
  display: -moz-box;
  display: -ms-flexbox;
  display: flex;
  flex-wrap: wrap;
  justify-content: center;
  align-items: center;
}

.row-ProtoNANO_soft {
  background-color: #eff6f9;
  border-radius: 10px;
  overflow: hidden;
  width: 98%;
  float: left;
  margin: 10px;
  display: block;
  text-align: left;
  padding-left: 10px;
  padding-top: 10px;
}

input.button-QMRF_ProtoNANO {
  outline: none !important;
  border: none;
  background: transparent;
  background-color: #a2b4ff;
  border-radius: 8px;
  padding: 3px 5px;
  width: 70px;
  text-align: center;
  cursor: pointer;
}

input.button-QMRF_ProtoNANO:hover {
  color: black;
  text-decoration: none;
  font-weight: bold;
}

.button-ProtoNANO_dark_alone {
  background-color: #0f3f94;
  border: none;
  color: #ecf0ff;
  border-radius: 8px;
  padding: 5px 10px;
  text-align: center;
  text-decoration: none;
  display: inline-block;
  font-size: 16px;
}
.button-ProtoNANO_soft_alone {
  background-color:#ecf0ff;
  border: none;
  color:  #0f3f94;
  border-radius: 8px;
  padding: 5px 10px;
  text-align: center;
  text-decoration: none;
  display: inline-block;
  font-size: 16px;
}


.button-ProtoNANO_dark_pair {
  background-color: #0f3f94;
  border: none;
  color: #ecf0ff;
  border-radius: 8px;
  padding: 5px 10px;
  margin-top: 15px;
  text-align: center;
  text-decoration: none;
  display: inline-block;
  font-size: 16px;
}

.button-ProtoNANO_soft_pair {
  background-color: #a2b4ff;
  border: none;
  color: black;
  border-radius: 8px;
  padding: 5px 10px;
  margin-left: 20px;
  text-align: center;
  text-decoration: none;
  display: inline-block;
  font-size: 16px;
}

.button-ProtoNANO_dark_alone[disabled] {
  background-color: #0f3f94;
  border: none;
  opacity: 0.5;
  color: #ecf0ff;
  border-radius: 8px;
  padding: 5px 10px;
  text-align: center;
  text-decoration: none;
  display: inline-block;
  font-size: 16px;
}

.button-ProtoNANO_dark_pair[disabled] {
  background-color: #0f3f94;
  border: none;
  opacity: 0.5;
  color: #ecf0ff;
  border-radius: 8px;
  padding: 5px 10px;
  margin-top: 15px;
  text-align: center;
  text-decoration: none;
  display: inline-block;
  font-size: 16px;
}

.foot-container {
  padding: 5px;
}

.foot-child {
  width: 50%;
  float: left;
  padding: 10px;
  ;
}

.Prototext_description_nano {
  text-align: center;
  vertical-align: middle;
  margin: 5px 5px 5px 5px;
  font-size: 1.1 vw;
}




.container-ProtoNANO_soft {
  align-items: left;
  padding: 15px;
  border-radius: 10px;
  background: #ecf0ff;
}


.container-ProtoNANO_dark {
  align-items: left;
  padding: 15px;
  border-radius: 10px;  
  /* background: #869FC9; */
  background: #0F3F94;
  color: #ecf0ff;
}




.row-ProtoNANO_soft {
  background-color: #ecf0ff;
  color: black;
  border-radius: 10px;
  overflow: hidden;
  width: 98%;
  float: left;
  margin: 10px;
  display: block;
  text-align: left;
  padding: 10px;
}

.par_help {

margin-bottom: 1em;
}


.radio_but {
    margin-left: 20px;
    margin-bottom: 0px;
    

}

.select_form {
  margin-left: 20px;
  margin-bottom: 0px;
  width: 40%;
  border-radius: 8px;
  border: #999999 1px solid;
  background-color: white;
  

}

.fa-eye {
  color: #333;
  margin-left: -30px; 
  cursor: pointer;

}
.fa-eye-slash {
  color: #666;
  margin-left: -30px; 
  cursor: pointer;


}

@media (max-width: 1024px) {
  .padding_cb {
    padding-top: 1px;
  } 
  .container-main-cover {    
    padding: 0;
  }

  .ProtoPREDStrech {
    width: 100%;
  }

     
}
@media (max-width: 991px) {
  .PHYSCHEMsoft{
    margin-bottom: 0;
  }

  .ProtoPREDmedbox{
    width: 400;
  }
  .ProtoPREDbgimg_border_alone3{
    width: 359px;
    margin: 20px 20px 20px 20px;
  }
  .ProtoPREDlogoboxGeneric,.ProtoDescriptionGeneric{
    width: 337px;
    margin-left: 30px;
  }
  .ProtoADMElogore {
    background-size: 220px;
  }
  .ProtoPHYSCHEMlogore  {
    background-size: 260px;
  }
  .ProtoTOXlogore, .ProtoECOlogore {
    background-size: 190px;
  }
  .ProtoPREDbckgboxGeneric {
    width: 350px;
    margin: 20px 20px 20px 20px;

  }
  .ProtoPREDbuttsGenerics {
    margin-left: 25;
    width: 130px;
    font-size: 16px;
  }
  .ProtoPREDbutts_2Generics {
    margin-left: 55px;
    width: 90px;
    font-size: 16px;
  }

  .ProtoADMEdescription, .ProtoPHYSCHEMdescription, .ProtoTOXdescription, .ProtoECOdescription, .ProtoEDdescription{
    width: 347px;
    margin-top: 95px;
    margin-left: 25px;
    height: 45;
  }

}

@media (max-width: 575px) {

  .containero_upper {
    height: 380;
  }
  
  .container-main-cover_lefter {
    padding: 5px;
  }
  .container-main-cover {    
    padding: 0;
  }

  .ProtoPREDStrech {
    width: 100%;
    
  }  
  .ProtoPREDlogoboxGeneric,.ProtoDescriptionGeneric{
    margin-left: 30px;
  }
  .GenoITSsoft, .ProtoNANOsoft, .ICHsoft , .REACHsoft, 
  .ADMEsoft, .PHYSCHEMsoft, .TOXsoft, .ECOsoft, .EDsoft{
    width: 100%;  
    height: 200px;  
  }

  .ProtoDescriptionGeneric {
    width: 80%;
    margin-left: 25px;
    margin-top: 95px;
  }

  .ProtoICHlogo, .ProtoREACHlogo,
  .ProtoADMElogore, .ProtoPHYSCHEMlogore, .ProtoTOXlogore, .ProtoECOlogore, .ProtoEDlogore {
    width: 80%;
    margin-top: 30px;
    margin-left: 25px;
  }

  .ProtoNANOlogo, .GenoITSlogo{
    width: 85%;
    margin-top: 30px;
    margin-left: 30px;
  }

  .ProtoNANObckgimg, .GenoITSbckgimg, .ProtoREACHbckgimg, .ProtoICHbckgimg,
  .ProtoADMEbckgimg, .ProtoPHYSCHEMbckgimg, .ProtoTOXbckgimg, .ProtoECObckgimg{
    width: 95%;
    height: 178px;
    margin: 5px;
  }

  .row .mid{
    display: flex;
    justify-content: space-around;
    align-items: center;
    margin-top: 145px;
  }

  .row .mid2 .column{
    display: flex;
    justify-content: space-around;
    align-items: center;
    
  }

  .row .mid .column .ProtoPREDbutts_2, 
  .row .mid .column .ProtoPREDbutts_2Generics,
  .row .mid2 .column .ProtoPREDbutts_2   {
    margin-left: 90;
    width: 100px;
  }

  .ProtoPREDbuttsGenerics {
    margin-left: 0;
    font-size: 16px;
  }

  
  .row .mid .column .ProtoPREDbuttsGenerics,
  .row .mid .column .ProtoPREDbutts  {
    margin-left: 0;
    margin-right: 5px;
    padding: 1px 6px;
  }

  .row .mid2 .column .ProtoPREDbutts{
    margin-left: 20;
  }

  .ProtoPREDlittlebox .mid{
    margin-top: 130px;
    margin-left: 30px;
  }

  
  .ProtoPREDbgimg_border_alone3,
  .ProtoPREDbgimg_border_alone4{
    width: 85%;
    height: 160px;
    margin: 20px 10px 10px 15px;
  }

  .ProtoPREDbgimg_border_alone_long{
    width: 92%;
    height: 160px;
    margin: 20px 10px 10px 15px;
  }

  .ICHdark, .REACHdark,.ProtoNANOdark, .GenoITSdark,
  .ADMEdark, .PHYSCHEMdark, .TOXdark, .ECOdark, .EDdark{
    width: 100%;
    height: 90px;
  }

  .ProtoICHdescription, .ProtoREACHdescription, .ProtoADMEdescription, .ProtoPHYSCHEMdescription, .ProtoTOXdescription, .ProtoECOdescription, .ProtoEDdescription
{
    width: 80%;
    margin-top: 95px;
    margin-left: 25px;
    height: 45;
  }

  .ProtoPREDlittlebox .ProtoNANOdescription, .ProtoPREDlittlebox .GenoITSdescription{
    width: 85%;
    margin-top: 95px;
    margin-left: 30px;
    height: 45;
  }

  .PROTOPREDSpeed, .ProtoPREDRegulatory {
    display: flex;
    flex-direction: column;
    
  }

  .mid2{    
    display: flex;
    justify-content: space-around;
    align-items: center;
    margin-right: 0;
    margin-top: 140px;
    margin-left: 0;
    width: 90%;
  }

  .mid{    
    display: flex;
    justify-content: space-around;
    align-items: center;
    margin-right: 0;
    margin-top: 148px;
    margin-left: 0;
    width: 90%;
  }

  .imagenQSAR{
    display: flex;
    flex-direction: column;
  }
 
  .ProtoPREDbutts_2Generics {
    margin-left: 55px;
  }
}

@media (max-width: 520px) {
  .ProtoPREDbgimg_border_alone3, .ProtoPREDbgimg_border_alone4 {
    margin: 20px 10px 10px 10px;
  }

  .ProtoPREDbgimg_border_alone_long {
    margin: 20px 5px 10px 8px;
  }

  .row .mid .column .ProtoPREDbuttsGenerics {
    margin-right: 38px;
    font-size: 16px;
  }

  .row .mid .column .ProtoPREDbutts_2, 
  .row .mid .column .ProtoPREDbutts_2Generics,
  .row .mid2 .column .ProtoPREDbutts_2   {
    margin-left: 10;
    width: 100px;
  }

  .ProtoNANOlogo, .GenoITSlogo{
    margin-left: 25px;
  }

  .ProtoPREDlittlebox .ProtoNANOdescription, .ProtoPREDlittlebox .GenoITSdescription{
    margin-left: 25px;
  }
}

@media (max-width: 425px) {

  .ProtoICHlogo, .ProtoREACHlogo,
  .ProtoADMElogore, .ProtoPHYSCHEMlogore, .ProtoTOXlogore, .ProtoECOlogore, .ProtoEDlogore {
    width: 81%;
  }
  .ProtoPREDbgimg_border_alone3, .ProtoPREDbgimg_border_alone4{
    margin-left: 1%;
    margin-right: 5;
  }

  .ProtoREACHlogo, .ProtoICHlogo, .ProtoICHdescription, .ProtoREACHdescription, .ProtoDescriptionGeneric, .ProtoPREDlogoboxGeneric, .ProtoEDdescription{
    margin-left: 3%;
  }

  .ProtoDescriptionGeneric{
    width: 81%
  }

  .ProtoNANOlogo, .ProtoPREDlittlebox .ProtoNANOdescription, .GenoITSlogo{
    margin-left: 5.5%;
  }
}